tirzepatide and alcohol addiction attenuates dopamine reward signaling suppresses drinking and relapse-like behaviors in rodents GLP-1 medications get at the

Appetite (hunger-fullness) is a mechanism controlled by many hormones

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Earlier medications often achieved modest weight loss (under 10% of body weight), and not all patients experienced optimal blood sugar control

Other diabetes medication classes offer alternatives if GLP-1 therapy proves unsuitable: SGLT2 inhibitors (such as dapagliflozin or empagliflozin) provide cardiovascular and renal benefits without affecting gastric emptying, though require adequate renal function and carry risks of genital infections and diabetic ketoacidosis DPP-4 inhibitors (such as sitagliptin) work on the incretin system but with less pronounced gastrointestinal effects note these should not be combined with GLP-1 receptor agonists Traditional agents including metformin, sulfonylureas, or insulin may be appropriate depending on individual circumstances Any medication change should be made in consultation with your diabetes specialist or GP, considering your overall glycaemic control, cardiovascular risk profile, and treatment goals, in line with NICE NG28 guidance